Endothelial Dysfunction and Preeclampsia
نویسندگان
چکیده
1. Protogerou AD, Blacher J, Mavrikakis M, Lekakis J, Safar ME: Increased pulse pressure amplification in treated hypertensive subjects with metabolic syndrome. Am J Hypertens 2007;20:127–133. 2. Safar ME, Smulyan H: Hypertension in women. Am J Hypertens 2007;17:82–87. 3. Safar ME: Systolic blood pressure, pulse pressure and arterial stiffness as cardiovascular risk factors. Curr Opin Nephrol Hypertens 2001;10:257–261. 4. Randall OS, Westerhof N, van den Bos GC, Alexander B: Reliability of stroke volume to pulse pressure ratio for estimating or detecting changes in arterial compliance. J Hypertens 1986;4(Suppl 5): S293–S296. 5. Stergiopulos N, Meister JJ, Westerhof N: Evaluation of methods for estimation of total arterial compliance. Am J Physiol Heart Circ Physiol 1995;268:H1540–H1548. 6. de Simone G, Roman MJ, Koren MJ, Mensah GA, Ganau A, Devereux RB: Stroke volume/pulse pressure ratio and cardiovascular risk in arterial hypertension. Hypertension 1999;33: 800 – 805. 7. Lind L, Andrén B, Sundström J: The stroke volume/pulse pressure ratio predicts coronary heart disease mortality in a population of elderly men. J Hypertens 2004;22:899–905. 8. Protogerou AD, Blacher J, Aslangul E, Le Jeunne C, Mavrikakis M, Lekakis J, Safar ME: Gender influence on metabolic syndrome’s effects on arterial stiffness and pressure wave reflections in treated hypertensive subjects. Atherosclerosis 2006;June 23 [Epub ahead of print].
منابع مشابه
Maternal Periodontitis, Preeclampsia and Adverse Pregnancy Outcomes
Background and Aim: Preeclampsia is a considerable problem of pregnancy. Endothelial dysfunction and placental hypoxia are the current hypothesis of preeclampsia. Chronic inflammation, including periodontitis may provoke systemic maternal and placental pro-inflammatory endothelial dysfunction, which represent a significant risk factor for diseases of vascular origin. So this study was carried o...
متن کاملRole of Enos (glu298asp) Gene Polymorphism and Intergenotypic Variation of Nitric Oxide and Inflammatory Cytokines in Preeclampsia. Deepika Sharma1*, Shubha. S. Trivedi and Jayashree Bhattacharjee
ABSTRACT Problem Multiple etiologies are available for understanding the mechanisms responsible for the syndrome of Preeclampsia. Cytokine imbalance and endothelial dysfunction is suggested to have a pivotal role. The pathophysiological processes in preeclampsia (PE) are also influenced by genetic factors. To characterize the host genetic factors determining the susceptibility to Preeclampsia, ...
متن کاملEndothelial cell dysfunction and cardiac hypertrophy in the STOX1 model of preeclampsia
Preeclampsia is a disease of pregnancy involving systemic endothelial dysfunction. However, cardiovascular consequences of preeclampsia are difficult to analyze in humans. The objective of the present study is to evaluate the cardiovascular dysfunction induced by preeclampsia by examining the endothelium of mice suffering of severe preeclampsia induced by STOX1 overexpression. Using Next Genera...
متن کاملTherapeutically targeting mitochondrial redox signalling alleviates endothelial dysfunction in preeclampsia
Aberrant placentation generating placental oxidative stress is proposed to play a critical role in the pathophysiology of preeclampsia. Unfortunately, therapeutic trials of antioxidants have been uniformly disappointing. There is provisional evidence implicating mitochondrial dysfunction as a source of oxidative stress in preeclampsia. Here we provide evidence that mitochondrial reactive oxygen...
متن کاملLoss of Thrombomodulin in Placental Dysfunction in Preeclampsia.
OBJECTIVE Preeclampsia is a pregnancy-specific syndrome characterized by placental dysfunction and an angiogenic imbalance. Systemically, levels of thrombomodulin, an endothelium- and syncytiotrophoblast-bound protein that regulates coagulation, inflammation, apoptosis, and tissue remodeling, are increased. We aimed to investigate placental thrombomodulin dysregulation and consequent downstream...
متن کاملElevated plasma endothelial microparticles in preeclampsia.
OBJECTIVE The purpose of this study was to assess endothelial dysfunction in women with preeclampsia by measuring endothelial microparticles. STUDY DESIGN A case-control study was conducted on 20 women with preeclampsia and 20 healthy pregnant women as control subjects. Endothelial microparticles were measured by flow cytometry with anti-CD31 and anti-CD42. CD31(+)/CD42(+) platelet microparti...
متن کامل